Category

    Termination Size

      Valved?

        Mounting Options

          Sterilization

            Bioprocessing

            For pharmaceutical manufacturers it can be just as hard to keep up with demand as it is to keep up with the highly competitive market. Now you can do both with easy-to-use single-use connectors from CPC. They help maintain flow path sterility and integrity while enabling you to improve production yields, decrease time-to-market and reduce costs. Our genderless sterile connectors simplify process integration, maximize flexibility and streamline your supply chain efficiencies.

                For mounting to the processing equipment, engineers may specify the connection with either a ¾” or 1-½” sanitary termination on the middle port. Tri-clover clamps are used to secure the middle sanitary to the equipment and the lower sanitary to the steam trap. Once attached, these two lower ports allow a true steam-through SIP process to eliminate potential “dead legs” that trap contaminants. With Steam-Thru® II, you can perform a SIP cycle of up to 135°C or 35 PSI for up to 60 minutes to “steam on” the connector to the equipment. Effectiveness of the “steam on” cycle was confirmed through bacterial challenge testing using Bacillus stearothermophilus performed at the University of Minnesota’s Biotechnology Research Center.

                Once the SIP cycle is complete, the operator simply depresses the thumb latch to allow valve transition from the steam position to the flow position. This creates a sterile flow path between the stainless equipment and the single-use system, allowing aseptic fluid transfer. A benefit of the Steam-Thru® II valve design is a maximum Cv value of 8.2, which translates to a flow rate of 43.9 liters per minute at 2 PSI, making it appropriate for high volume applications.

                After fluid transfer is complete, depressing the thumb latch again allows repositioning of the valve back to the steam position for a second SIP or “steam off” cycle. This eliminates any biologic residual remaining between the process equipment and the single-use system, minimizing the potential for environmental contamination at disconnection.

                In addition to the bacterial challenge testing completed on the “steam on” cycle, bacterial challenge tests were performed following media transfer on the “steam off” cycle. Bacterial ingress tests using Brevendimonas diminuta were conducted by Northview Labs to verify post-sterilization seal performance. Other performance tests, including helium/steam leak, tensile and maximum burst were completed to assure design and process integrity. The Steam-Thru® II is comprised of non-animal origin USP Class VI polysulfone and platinum-cured silicone seals, which were tested for biocompatibility.

             

            Single-Use Applications

            Transfer Lines

                Especially in multiproduct facilities, the risk of cross contamination in the suite-to-suite transfer process is high and can potentially lead to product loss or reduced production yields. Pre-sterilized, single-use assemblies reduce these risks and improve the speed and safety of drug development and delivery.

            Single-Use Transfer Lines: Final Fill Operations

                Traditionally, final fill operations included stainless steel equipment connected via reusable valves, rigid tubing and steel pipes. Today, many process engineers are designing this operation with single-use transfer lines instead of stainless steel equipment to reduce sterilization time and cost.

                Final fill tanks are designed to transfer formulated product from formulation suites to storage areas and ultimately to filling suites. To allow sterile connection to and from these vessels, designers traditionally added three-way valve assemblies to fill and drain ports. Replacing these heavy assemblies with single-use transfer lines and connectors eliminates cleaning validation and maintenance, while reducing mobile vessel weight by tens of kilograms.

             

            Sterility Assurance
            Filter Integrity Testing
             

            Product

            Bodies

            MHQC17000 product photo

            MHQC17000

            MHQC17000
            Hybrid (Mini) Connector, Inline body, 4’ (1.2m) umbilical with 1/16” (3.2mm) ID tube, (2) 22 gauge wires
            Product ID: MHQC17000
            TFB10 product photo

            TFB10

            TFB10
            Tentube Coupling Body Without Fitting Inserts
            Product ID: TFB10

            Color Coding and Keying

            DQPROKEYDIRED01 product photo

            DQPROKEYDIRED01

            DQPROKEYDIRED01
            Key Kit for Drum Coupling Insert, Molded Red
            Product ID: DQPROKEYDIRED01
            DQPROKEYDIBLU05 product photo

            DQPROKEYDIBLU05

            DQPROKEYDIBLU05
            Key Kit for Drum Coupling Insert, Molded Blue
            Product ID: DQPROKEYDIBLU05
            DQPROKEYCPBLK99 product photo

            DQPROKEYCPBLK99

            DQPROKEYCPBLK99
            Key Kit for Coupler, Molded Black
            Product ID: DQPROKEYCPBLK99
            DQPURKEYCPBLU05 product photo

            DQPURKEYCPBLU05

            DQPURKEYCPBLU05
            Key Kit for Coupler - Molded Blue
            Product ID: DQPURKEYCPBLU05
            DQPURKEYDIBRN04 product photo

            DQPURKEYDIBRN04

            DQPURKEYDIBRN04
            Key Kit for Drum Coupling Insert - Molded Brown
            Product ID: DQPURKEYDIBRN04
            DQPURKEYCPRED01 product photo

            DQPURKEYCPRED01

            DQPURKEYCPRED01
            Key Kit for Coupler - Molded Red
            Product ID: DQPURKEYCPRED01
            DQPROKEYCPGRY00 product photo

            DQPROKEYCPGRY00

            DQPROKEYCPGRY00
            Key Kit for Coupler, Molded Grey
            Product ID: DQPROKEYCPGRY00
            DQPROKEYCPBLU05 product photo

            DQPROKEYCPBLU05

            DQPROKEYCPBLU05
            Key Kit for Coupler, Molded Blue
            Product ID: DQPROKEYCPBLU05

            Genderless

            AQS17MPC product photo

            AQS17MPC

            AQS17MPC
            Genderless AseptiQuik S Connector with MPC Insert
            Product ID: AQS17MPC
            AQS17MPCHT product photo

            AQS17MPCHT

            AQS17MPCHT
            Genderless AseptiQuik S Connector with MPC Insert, High Temperature
            Product ID: AQS17MPCHT