Category

    Termination Size

    • 1/8"

    Valved?

      Mounting Options

        Bioprocessing

        For pharmaceutical manufacturers it can be just as hard to keep up with demand as it is to keep up with the highly competitive market. Now you can do both with easy-to-use single-use connectors from CPC. They help maintain flow path sterility and integrity while enabling you to improve production yields, decrease time-to-market and reduce costs. Our genderless sterile connectors simplify process integration, maximize flexibility and streamline your supply chain efficiencies.

            For mounting to the processing equipment, engineers may specify the connection with either a ¾” or 1-½” sanitary termination on the middle port. Tri-clover clamps are used to secure the middle sanitary to the equipment and the lower sanitary to the steam trap. Once attached, these two lower ports allow a true steam-through SIP process to eliminate potential “dead legs” that trap contaminants. With Steam-Thru® II, you can perform a SIP cycle of up to 135°C or 35 PSI for up to 60 minutes to “steam on” the connector to the equipment. Effectiveness of the “steam on” cycle was confirmed through bacterial challenge testing using Bacillus stearothermophilus performed at the University of Minnesota’s Biotechnology Research Center.

            Once the SIP cycle is complete, the operator simply depresses the thumb latch to allow valve transition from the steam position to the flow position. This creates a sterile flow path between the stainless equipment and the single-use system, allowing aseptic fluid transfer. A benefit of the Steam-Thru® II valve design is a maximum Cv value of 8.2, which translates to a flow rate of 43.9 liters per minute at 2 PSI, making it appropriate for high volume applications.

            After fluid transfer is complete, depressing the thumb latch again allows repositioning of the valve back to the steam position for a second SIP or “steam off” cycle. This eliminates any biologic residual remaining between the process equipment and the single-use system, minimizing the potential for environmental contamination at disconnection.

            In addition to the bacterial challenge testing completed on the “steam on” cycle, bacterial challenge tests were performed following media transfer on the “steam off” cycle. Bacterial ingress tests using Brevendimonas diminuta were conducted by Northview Labs to verify post-sterilization seal performance. Other performance tests, including helium/steam leak, tensile and maximum burst were completed to assure design and process integrity. The Steam-Thru® II is comprised of non-animal origin USP Class VI polysulfone and platinum-cured silicone seals, which were tested for biocompatibility.

         

        Single-Use Applications

        Transfer Lines

            Especially in multiproduct facilities, the risk of cross contamination in the suite-to-suite transfer process is high and can potentially lead to product loss or reduced production yields. Pre-sterilized, single-use assemblies reduce these risks and improve the speed and safety of drug development and delivery.

        Single-Use Transfer Lines: Final Fill Operations

            Traditionally, final fill operations included stainless steel equipment connected via reusable valves, rigid tubing and steel pipes. Today, many process engineers are designing this operation with single-use transfer lines instead of stainless steel equipment to reduce sterilization time and cost.

            Final fill tanks are designed to transfer formulated product from formulation suites to storage areas and ultimately to filling suites. To allow sterile connection to and from these vessels, designers traditionally added three-way valve assemblies to fill and drain ports. Replacing these heavy assemblies with single-use transfer lines and connectors eliminates cleaning validation and maintenance, while reducing mobile vessel weight by tens of kilograms.

         

        Sterility Assurance
        Filter Integrity Testing
         

        Product

        Bodies

        PLQ2D3102BLU product photo

        PLQ2D3102BLU

        PLQ2D3102BLU
        1/8" G-Thread/BSPP Valved In-line Liquid Cooling Body, Cool Blue
        Product ID: PLQ2D3102BLU
        PLQ2D3102RED product photo

        PLQ2D3102RED

        PLQ2D3102RED
        1/8" G-Thread/BSPP Valved In-line Liquid Cooling Body, Warm Red
        Product ID: PLQ2D3102RED
        SRC1702CL product photo

        SRC1702CL

        SRC1702CL
        1/8 Hose Barb Coupling Body - ISO Class 7 Cleanroom Version
        Product ID: SRC1702CL
        SMF10297 product photo

        SMF10297

        SMF10297
        1/8 Hose Barb Non-Valved In-Line Disposable Coupling Body
        Product ID: SMF10297
        BSQ1702 product photo

        BSQ1702

        BSQ1702
        1/8 Hose Barb Body
        Product ID: BSQ1702
        PMC160212 product photo

        PMC160212

        PMC160212
        1/8 Hose Barb Non-Valved Panel Mount Coupling Body
        Product ID: PMC160212
        SMPT0212 product photo

        SMPT0212

        SMPT0212
        1/8 NPT Non-Valved Coupling Body
        Product ID: SMPT0212
        MC1002BSPT product photo

        MC1002BSPT

        MC1002BSPT
        1/8 BSPT Non-Valved Coupling Body
        Product ID: MC1002BSPT
        PMCD160212 product photo

        PMCD160212

        PMCD160212
        1/8 Hose Barb Valved Panel Mount Coupling Body
        Product ID: PMCD160212
        PMC100212 product photo

        PMC100212

        PMC100212
        1/8 NPT Non-Valved Coupling Body
        Product ID: PMC100212

        Genderless

        AQS17002 product photo

        AQS17002

        AQS17002
        1/8" Hose Barb Genderless AseptiQuik S Connector
        Product ID: AQS17002
        AQS17002HT product photo

        AQS17002HT

        AQS17002HT
        1/8" Hose Barb Genderless AseptiQuik S Connector, High Temperature
        Product ID: AQS17002HT